1,2,4-Triazole
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1,2,4-Triazole | |
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IUPAC name | 1H-1,2,4-triazole |
Other names | 1,2,4-triazole pyrrodiazole |
Identifiers | |
CAS number | [288-88-0] |
PubChem | |
SMILES | C1 = NC = NN1 |
Properties | |
Molecular formula | C2H3N3 |
Molar mass | 69.0654 |
Appearance | white solid |
Melting point |
120-121 |
Boiling point |
260 |
Solubility in water | very soluble |
Acidity (pKa) | 2.2 |
Basicity (pKb) | 10.3 |
Hazards | |
Flash point | 140 |
Related compounds | |
Related compounds | 1,2,3-triazole imidazole |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.
1,2,4-Triazoles can be prepared using the Einhorn-Brunner reaction or the Pellizzari reaction.[1]
[edit] References
- ^ Potts K. T. (1961). "The Chemistry of 1,2,4-Triazoles.". Chemical Reviews 61 (2): 87–127. doi: .