(tyrosine 3-monooxygenase) kinase

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In enzymology, a [tyrosine 3-monooxygenase] kinase (EC 2.7.11.6) is an enzyme that catalyzes the chemical reaction

ATP + [tyrosine-3-monooxygenase] $\rightleftharpoons$ ADP + phospho-[tyrosine-3-monooxygenase]

Thus, the two substrates of this enzyme are ATP and [[[tyrosine-3-monooxygenase]]], whereas its two products are ADP and [[phospho-[tyrosine-3-monooxygenase]]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates in mapk signaling pathway and non-small cell lung cancer.

[edit] References

IUBMB entry for 2.7.11.6
BRENDA references for 2.7.11.6 (Recommended.)
PubMed references for 2.7.11.6
PubMed Central references for 2.7.11.6
Google Scholar references for 2.7.11.6
Pigeon D, Drissi-Daoudi R, Gros F, Thibault J (1986). "[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]". C. R. Acad. Sci. III. 302: 435–8. PMID 2872947.
Pigeon D, Ferrara P, Gros F, Thibault J (1987). "Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase". J. Biol. Chem. 262: 6155–8. PMID 2883182.