(S)-methylmalonyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a (S)-methylmalonyl-CoA hydrolase (EC 3.1.2.17) is an enzyme that catalyzes the chemical reaction

(S)-methylmalonyl-CoA + H₂O methylmalonate + CoA

Thus, the two substrates of this enzyme are (S)-methylmalonyl-CoA and H₂O, whereas its two products are methylmalonate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase. This enzyme participates in propanoate metabolism.

[edit] References

• IUBMB entry for 3.1.2.17
• BRENDA references for 3.1.2.17 (Recommended.)
• PubMed references for 3.1.2.17
• PubMed Central references for 3.1.2.17
• Google Scholar references for 3.1.2.17
• Kovachy RJ, Copley SD, Allen RH (1983). "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase". J. Biol. Chem. 258: 11415–21. PMID 6885824. 

[edit] External links

The CAS registry number for this enzyme class is 87928-03-8.

• IUBMB entry for 3.1.2.17

• KEGG entry for 3.1.2.17

• BRENDA entry for 3.1.2.17

• NiceZyme view of 3.1.2.17

• EC2PDB: PDB structures for 3.1.2.17

• PRIAM entry for 3.1.2.17

• PUMA2 entry for 3.1.2.17

• IntEnz: Integrated Enzyme entry for 3.1.2.17

• MetaCyc entry for 3.1.2.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047511: (S)-methylmalonyl-CoA hydrolase

• AMIGO entry for GO code 0047511: (S)-methylmalonyl-CoA hydrolase