(S)-mandelate dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a (S)-mandelate dehydrogenase (EC 1.1.99.31) is an enzyme that catalyzes the chemical reaction
- (S)-2-hydroxy-2-phenylacetate + acceptor 2-oxo-2-phenylacetate + reduced acceptor
Thus, the two substrates of this enzyme are (S)-2-hydroxy-2-phenylacetate and acceptor, whereas its two products are 2-oxo-2-phenylacetate and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase. This enzyme is also called MDH.
[edit] References
- IUBMB entry for 1.1.99.31
- BRENDA references for 1.1.99.31 (Recommended.)
- PubMed references for 1.1.99.31
- PubMed Central references for 1.1.99.31
- Google Scholar references for 1.1.99.31
- Lehoux IE, Mitra B (1999). "(S)-Mandelate dehydrogenase from Pseudomonas putida: mechanistic studies with alternate substrates and pH and kinetic isotope effects". Biochemistry. 38: 5836–48. doi: . PMID 10231535.
- Dewanti AR, Xu Y, Mitra B (2004). "Role of glycine 81 in (S)-mandelate dehydrogenase from Pseudomonas putida in substrate specificity and oxidase activity". Biochemistry. 43: 10692–700. doi: . PMID 15311930.
- Dewanti AR, Xu Y, Mitra B (2004). "Esters of mandelic acid as substrates for (S)-mandelate dehydrogenase from Pseudomonas putida: implications for the reaction mechanism". Biochemistry. 43: 1883–90. doi: . PMID 14967029.