(S)-2-methylmalate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a (S)-2-methylmalate dehydratase (EC 4.2.1.34) is an enzyme that catalyzes the chemical reaction

(S)-2-methylmalate 2-methylfumarate + H₂O

Hence, this enzyme has one substrate, (S)-2-methylmalate, and two products, 2-methylfumarate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-2-methylmalate hydro-lyase (2-methylfumarate-forming). Other names in common use include mesaconate hydratase, (+)-citramalate hydro-lyase, L-citramalate hydrolase, citramalate dehydratase, (+)-citramalic hydro-lyase, mesaconate mesaconase, mesaconase, and (S)-2-methylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 4.2.1.34
• BRENDA references for 4.2.1.34 (Recommended.)
• PubMed references for 4.2.1.34
• PubMed Central references for 4.2.1.34
• Google Scholar references for 4.2.1.34
• Blair AH, Barker HA (1966). "Assay and purification of (+)-citramalate hydro-lyase components from Clostridium tetanomorphum". J. Biol. Chem. 241: 400–8. PMID 5903732. 
• Wang CC, Barker HA (1969). "Purification and properties of L-citramalate hydrolyase". J. Biol. Chem. 244: 2516–26. PMID 5769987. 

[edit] External links

The CAS registry number for this enzyme class is 9027-94-5.

• IUBMB entry for 4.2.1.34

• KEGG entry for 4.2.1.34

• BRENDA entry for 4.2.1.34

• NiceZyme view of 4.2.1.34

• EC2PDB: PDB structures for 4.2.1.34

• PRIAM entry for 4.2.1.34

• PUMA2 entry for 4.2.1.34

• IntEnz: Integrated Enzyme entry for 4.2.1.34

• MetaCyc entry for 4.2.1.34

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047510: (S)-2-methylmalate dehydratase

• AMIGO entry for GO code 0047510: (S)-2-methylmalate dehydratase