(RNA-polymerase)-subunit kinase

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In enzymology, a [RNA-polymerase]-subunit kinase (EC 2.7.11.23) is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase] ADP + phospho-[DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and [[[DNA-directed RNA polymerase]]], whereas its two products are ADP and [[phospho-[DNA-directed RNA polymerase]]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.

[edit] References

• IUBMB entry for 2.7.11.23
• BRENDA references for 2.7.11.23 (Recommended.)
• PubMed references for 2.7.11.23
• PubMed Central references for 2.7.11.23
• Google Scholar references for 2.7.11.23
• Lee JM, Greenleaf AL (1989). "A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II". Proc. Natl. Acad. Sci. U. S. A. 86: 3624–8. PMID 2657724. 

[edit] External links

The CAS registry number for this enzyme class is 122097-00-1.

• IUBMB entry for 2.7.11.23

• KEGG entry for 2.7.11.23

• BRENDA entry for 2.7.11.23

• NiceZyme view of 2.7.11.23

• EC2PDB: PDB structures for 2.7.11.23

• PRIAM entry for 2.7.11.23

• PUMA2 entry for 2.7.11.23

• IntEnz: Integrated Enzyme entry for 2.7.11.23

• MetaCyc entry for 2.7.11.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008353: RNA polymerase subunit kinase

• AMIGO entry for GO code 0008353: RNA polymerase subunit kinase