(ribulose-bisphosphate carboxylase)-lysine N-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase (EC 2.1.1.127) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine $\rightleftharpoons$ S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N₆-methyl-L-lysine

Thus, the two substrates of this enzyme are S-adenosyl methionine and [[[ribulose-1,5-bisphosphate carboxylase]-lysine]], whereas its two products are S-adenosylhomocysteine and [[[ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine]].

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine N6-methyltransferase. Other names in common use include rubisco methyltransferase, ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase, ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit, epsilonN-methyltransferase, S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase, and (dimerizing)]-lysine 6-N-methyltransferase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1MLV, 1OZV, 1P0Y, 2H21, 2H23, 2H2E, and 2H2J.

[edit] References

IUBMB entry for 2.1.1.127
BRENDA references for 2.1.1.127 (Recommended.)
PubMed references for 2.1.1.127
PubMed Central references for 2.1.1.127
Google Scholar references for 2.1.1.127
Wang P, Royer M, Houtz RL (1995). "Affinity purification of ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilon N-methyltransferase". Protein. Expr. Purif. 6: 528–36. doi:10.1006/prep.1995.1070. PMID 8527940.
Ying Z, Janney N, Houtz RL (1996). "Organization and characterization of the ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilon N-methyltransferase gene in tobacco". Plant. Mol. Biol. 32: 663–71. doi:10.1007/BF00020207. PMID 8980518.