(R,R)-butanediol dehydrogenase

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In enzymology, a (R,R)-butanediol dehydrogenase (EC 1.1.1.4) is an enzyme that catalyzes the chemical reaction

(R,R)-butane-2,3-diol + NAD⁺ $\rightleftharpoons$ (R)-acetoin + NADH + H⁺

Thus, the two substrates of this enzyme are (R,R)-butane-2,3-diol and NAD⁺, whereas its 3 products are (R)-acetoin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R,R)-butane-2,3-diol:NAD+ oxidoreductase. Other names in common use include butyleneglycol dehydrogenase, D-butanediol dehydrogenase, D-(-)-butanediol dehydrogenase, butylene glycol dehydrogenase, diacetyl (acetoin) reductase, D-aminopropanol dehydrogenase, D-aminopropanol dehydrogenase, 1-amino-2-propanol dehydrogenase, 2,3-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, (R)-diacetyl reductase, (R)-2,3-butanediol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, 1-amino-2-propanol oxidoreductase, and aminopropanol oxidoreductase. This enzyme participates in butanoic acid metabolism.

[edit] References

IUBMB entry for 1.1.1.4
BRENDA references for 1.1.1.4 (Recommended.)
PubMed references for 1.1.1.4
PubMed Central references for 1.1.1.4
Google Scholar references for 1.1.1.4
Strecker HJ and Harary I (1954). "Bacterial butylene glycol dehydrogenase and diacetyl reductase". J. Biol. Chem. 211: 263–270.
Taylor MB and Juni E (1960). "Stereoisomeric specificities of 2,3-butanediol dehydrogenase". Biochim. Biophys. Acta 39: 448–457. doi:10.1016/0006-3002(60)90197-9.