(R)-limonene synthase

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In enzymology, a (R)-limonene synthase (EC 4.2.3.20) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate $\rightleftharpoons$ (+)-(4R)-limonene + diphosphate

Hence, this enzyme has one substrate, geranyl diphosphate, and two products, (+)-(4R)-limonene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming]. Other names in common use include (+)-limonene synthase, and geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming]. This enzyme participates in monoterpenoid biosynthesis.

[edit] References

IUBMB entry for 4.2.3.20
BRENDA references for 4.2.3.20 (Recommended.)
PubMed references for 4.2.3.20
PubMed Central references for 4.2.3.20
Google Scholar references for 4.2.3.20
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Bouwmeester HJ, Verhoeven HA (2002). "Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases". Eur. J. Biochem. 269: 3160–71. doi:10.1046/j.1432-1033.2002.02985.x. PMID 12084056.
Maruyama T, Ito M, Kiuchi F, Honda G (2001). "Molecular cloning, functional expression and characterization of d-limonene synthase from Schizonepeta tenuifolia". Biol. Pharm. Bull. 24: 373–7. doi:10.1248/bpb.24.373. PMID 11305598.