(R)-dehydropantoate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a (R)-dehydropantoate dehydrogenase (EC 1.2.1.33) is an enzyme that catalyzes the chemical reaction

(R)-4-dehydropantoate + NAD⁺ + H₂O (R)-3,3-dimethylmalate + NADH + 2 H⁺

The 3 substrates of this enzyme are (R)-4-dehydropantoate, NAD⁺, and H₂O, whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

[edit] References

• IUBMB entry for 1.2.1.33
• BRENDA references for 1.2.1.33 (Recommended.)
• PubMed references for 1.2.1.33
• PubMed Central references for 1.2.1.33
• Google Scholar references for 1.2.1.33
• Magee PT, Snell EE (1966). "The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate". Biochemistry. 5: 409–16. PMID 4287371. 

[edit] External links

The CAS registry number for this enzyme class is 37250-96-7.

• IUBMB entry for 1.2.1.33

• KEGG entry for 1.2.1.33

• BRENDA entry for 1.2.1.33

• NiceZyme view of 1.2.1.33

• EC2PDB: PDB structures for 1.2.1.33

• PRIAM entry for 1.2.1.33

• PUMA2 entry for 1.2.1.33

• IntEnz: Integrated Enzyme entry for 1.2.1.33

• MetaCyc entry for 1.2.1.33

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047509: (R)-dehydropantoate dehydrogenase

• AMIGO entry for GO code 0047509: (R)-dehydropantoate dehydrogenase