(R)-4-hydroxyphenyllactate dehydrogenase

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In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) is an enzyme that catalyzes the chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ $\rightleftharpoons$ 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.

[edit] References

IUBMB entry for 1.1.1.222
BRENDA references for 1.1.1.222 (Recommended.)
PubMed references for 1.1.1.222
PubMed Central references for 1.1.1.222
Google Scholar references for 1.1.1.222
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Leelayoova S, Marbury D, Rainey PM, Mackenzie NE, Hall JE (1992). "In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes". J. Protozool. 39 (2): 350–8. PMID 1578411.