(R)-2-methylmalate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a (R)-2-methylmalate dehydratase (EC 4.2.1.35) is an enzyme that catalyzes the chemical reaction

(R)-2-methylmalate 2-methylmaleate + H₂O

Hence, this enzyme has one substrate, (R)-2-methylmalate, and two products, 2-methylmaleate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming). Other names in common use include citraconate hydratase, citraconase, citramalate hydro-lyase, (-)-citramalate hydro-lyase, and (R)-2-methylmalate hydro-lyase. This enzyme participates in valine, leucine and isoleucine biosynthesis and c5-branched dibasic acid metabolism. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 4.2.1.35
• BRENDA references for 4.2.1.35 (Recommended.)
• PubMed references for 4.2.1.35
• PubMed Central references for 4.2.1.35
• Google Scholar references for 4.2.1.35
• Subramanian SS, Rao MR (1968). "Purification and properties of citraconase". J. Biol. Chem. 243: 2367–72. PMID 4296839. 

[edit] External links

The CAS registry number for this enzyme class is 9027-92-3.

• IUBMB entry for 4.2.1.35

• KEGG entry for 4.2.1.35

• BRENDA entry for 4.2.1.35

• NiceZyme view of 4.2.1.35

• EC2PDB: PDB structures for 4.2.1.35

• PRIAM entry for 4.2.1.35

• PUMA2 entry for 4.2.1.35

• IntEnz: Integrated Enzyme entry for 4.2.1.35

• MetaCyc entry for 4.2.1.35

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047508: (R)-2-methylmalate dehydratase

• AMIGO entry for GO code 0047508: (R)-2-methylmalate dehydratase