(R)-2-hydroxy-fatty-acid dehydrogenase

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In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.98) is an enzyme that catalyzes the chemical reaction

(R)-2-hydroxystearate + NAD⁺ 2-oxostearate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-2-hydroxystearate and NAD⁺, whereas its 3 products are 2-oxostearate, NADH, and H⁺. This reaction is important in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

[edit] References

• IUBMB entry for 1.1.1.98
• BRENDA references for 1.1.1.98 (Recommended.)
• PubMed references for 1.1.1.98
• PubMed Central references for 1.1.1.98
• Google Scholar references for 1.1.1.98
• Levis GM (1970). "2-Hydroxy fatty acid oxidases of rat kidney". Biochem. Biophys. Res. Commun. 38: 470–7. doi:10.1016/0006-291X(70)90737-0. PMID 5443694. 

[edit] External links

The CAS registry number for this enzyme class is 37250-32-1.

• IUBMB entry for 1.1.1.98

• KEGG entry for 1.1.1.98

• BRENDA entry for 1.1.1.98

• NiceZyme view of 1.1.1.98

• EC2PDB: PDB structures for 1.1.1.98

• PRIAM entry for 1.1.1.98

• PUMA2 entry for 1.1.1.98

• IntEnz: Integrated Enzyme entry for 1.1.1.98

• MetaCyc entry for 1.1.1.98

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047049: (R)-2-hydroxy-fatty-acid dehydrogenase

• AMIGO entry for GO code 0047049: (R)-2-hydroxy-fatty-acid dehydrogenase