(R)-2-haloacid dehalogenase

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In enzymology, a (R)-2-haloacid dehalogenase (EC 3.8.1.9) is an enzyme that catalyzes the chemical reaction

(R)-2-haloacid + H₂O $\rightleftharpoons$ (S)-2-hydroxyacid + halide

Thus, the two substrates of this enzyme are (R)-2-haloacid and H₂O, whereas its two products are (S)-2-hydroxyacid and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is (R)-2-haloacid halidohydrolase. Other names in common use include 2-haloalkanoic acid dehalogenase[ambiguous], 2-haloalkanoid acid halidohydrolase[ambiguous], D-2-haloacid dehalogenase, and D-DEX.

[edit] References

IUBMB entry for 3.8.1.9
BRENDA references for 3.8.1.9 (Recommended.)
PubMed references for 3.8.1.9
PubMed Central references for 3.8.1.9
Google Scholar references for 3.8.1.9
Smith JM, Harrison K, Colby J (1990). "Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23". J. Gen. Microbiol. 136: 881–6. PMID 2380688.
Leigh JA, Skinner AJ and Cooper RA (1988). "Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species". FEMS Microbiol. Lett. 49: 353–356. doi:10.1111/j.1574-6968.1988.tb02756.x.
M, Tsunasawa S and Esaki N (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68: 2097–2103. doi:10.1351/pac199668112097.