(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) is an enzyme that catalyzes the chemical reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H₂O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

Thus, the two substrates of this enzyme are [[[pyruvate dehydrogenase (acetyl-transferring)] phosphate]] and H₂O, whereas its two products are [[[pyruvate dehydrogenase (acetyl-transferring)]]] and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.

[edit] References

• IUBMB entry for 3.1.3.43
• BRENDA references for 3.1.3.43 (Recommended.)
• PubMed references for 3.1.3.43
• PubMed Central references for 3.1.3.43
• Google Scholar references for 3.1.3.43
• Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148: 327–42. PMID 4401694. 
• Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. 27: 41–9. PMID 3004826. 

[edit] External links

The CAS registry number for this enzyme class is 9073-70-5.

• IUBMB entry for 3.1.3.43

• KEGG entry for 3.1.3.43

• BRENDA entry for 3.1.3.43

• NiceZyme view of 3.1.3.43

• EC2PDB: PDB structures for 3.1.3.43

• PRIAM entry for 3.1.3.43

• PUMA2 entry for 3.1.3.43

• IntEnz: Integrated Enzyme entry for 3.1.3.43

• MetaCyc entry for 3.1.3.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004741: [pyruvate dehydrogenase (lipoamide) phosphatase]

• AMIGO entry for GO code 0004741: [pyruvate dehydrogenase (lipoamide) phosphatase]