(heparan sulfate)-glucosamine N-sulfotransferase

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In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-N-sulfoglucosamine]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase. Other names in common use include heparin N-sulfotransferase, 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase, PAPS:N-desulfoheparin sulfotransferase, PAPS:DSH sulfotransferase, N-HSST, N-heparan sulfate sulfotransferase, heparan sulfate N-deacetylase/N-sulfotransferase, heparan sulfate 2-N-sulfotransferase, heparan sulfate N-sulfotransferase, heparan sulfate sulfotransferase, N-desulfoheparin sulfotransferase, desulfoheparin sulfotransferase, 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase, heparitin sulfotransferase, and 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase.

[edit] References

• IUBMB entry for 2.8.2.8
• BRENDA references for 2.8.2.8 (Recommended.)
• PubMed references for 2.8.2.8
• PubMed Central references for 2.8.2.8
• Google Scholar references for 2.8.2.8
• Suzuki S, Trenn RH and Strominger JL (1961). "Separation of specific mucopolysaccharide sulfotransferases". Biochim. Biophys. Acta 50: 169–174. 
• Eisenman RA, Balasubramanian AS, Marx W (1967). "3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction". Arch. Biochem. Biophys. 119: 387–97. PMID 4964017. 
• Johnson AH, Baker JR (1973). "The enzymatic sulphation of heparan sulphate by hen's uterus". Biochim. Biophys. Acta. 320: 341–51. PMID 4270798. 

[edit] External links

The CAS registry number for this enzyme class is 9026-75-9.

• IUBMB entry for 2.8.2.8

• KEGG entry for 2.8.2.8

• BRENDA entry for 2.8.2.8

• NiceZyme view of 2.8.2.8

• EC2PDB: PDB structures for 2.8.2.8

• PRIAM entry for 2.8.2.8

• PUMA2 entry for 2.8.2.8

• IntEnz: Integrated Enzyme entry for 2.8.2.8

• MetaCyc entry for 2.8.2.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0015016: [heparan sulfate-glucosamine N-sulfotransferase]

• AMIGO entry for GO code 0015016: [heparan sulfate-glucosamine N-sulfotransferase]