(heparan sulfate)-glucosamine 3-sulfotransferase 1

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'In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 (EC 2.8.2.23) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine $\rightleftharpoons$ adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and [[[heparan sulfate]-glucosamine]], whereas its two products are adenosine 3',5'-bisphosphate and [[[heparan sulfate]-glucosamine 3-sulfate]].

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. Other names in common use include heparin-glucosamine 3-O-sulfotransferase, 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase, glucosaminyl 3-O-sulfotransferase, heparan sulfate D-glucosaminyl 3-O-sulfotransferase, and isoform/isozyme 1 (3-OST-1, HS3ST1). This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1VKJ and 1ZRH.

[edit] References

IUBMB entry for 2.8.2.23
BRENDA references for 2.8.2.23 (Recommended.)
PubMed references for 2.8.2.23
PubMed Central references for 2.8.2.23
Google Scholar references for 2.8.2.23
Kusche M, Backstrom G, Riesenfeld J, Petitou M, Choay J, Lindahl U (1988). "Biosynthesis of heparin. O-sulfation of the antithrombin-binding region". J. Biol. Chem. 263: 15474–84. PMID 3139669.
Shworak NW, Fritze LM, Liu J, Butler LD, Rosenberg RD (1996). "Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting converting activity that modifies an excess precursor pool". J. Biol. Chem. 271: 27063–71. PMID 8900197.
Liu J, Shworak NW, Fritze LM, Edelberg JM, Rosenberg RD (1996). "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase". J. Biol. Chem. 271: 27072–82. PMID 8900198.
Rosenberg RD (1997). "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase". J. Biol. Chem. 272: 28008–19. PMID 9346953.
Zhang L, Yoshida K, Liu J, Rosenberg RD (1999). "Anticoagulant heparan sulfate precursor structures in F9 embryonal carcinoma cells". J. Biol. Chem. 274: 5681–91. PMID 10026187.
RD (2001). "The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate". J. Biol. Chem. 276: 28806–13. PMID 11375390.