(citrate (pro-3S)-lyase) ligase

From Wikipedia, the free encyclopedia

In enzymology, a [citrate (pro-3S)-lyase] ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction

ATP + acetate + [citrate (pro-3S)-lyase](thiol form) AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form)

The 3 substrates of this enzyme are ATP, acetate, and [[[citrate (pro-3S)-lyase](thiol form)]], whereas its 3 products are AMP, diphosphate, and [[[citrate (pro-3S)-lyase](acetyl form)]].

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetate:[citrate-(pro-3S)-lyase](thiol-form) ligase (AMP-forming). Other names in common use include citrate lyase ligase, citrate lyase synthetase, acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP), acetate:HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two-component system - general.

[edit] References

• IUBMB entry for 6.2.1.22
• BRENDA references for 6.2.1.22 (Recommended.)
• PubMed references for 6.2.1.22
• PubMed Central references for 6.2.1.22
• Google Scholar references for 6.2.1.22
• Antranikian G, Gottschalk G (1982). "Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes". Eur. J. Biochem. 126: 43–7. doi:10.1111/j.1432-1033.1982.tb06743.x. PMID 7128585. 
• Antranikian G, Herzberg C, Gottschalk G (1985). "Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation". Eur. J. Biochem. 153: 413–20. doi:10.1111/j.1432-1033.1985.tb09318.x. PMID 3935436. 
• Quentmeier A, Antranikian G (1985). "Characterization of citrate lyase from Clostridium sporosphaeroides". Arch. Microbiol. 141: 85–90. doi:10.1007/BF00446745. PMID 3994485. 
• Schmellenkamp H, Eggerer H (1974). "Mechanism of enzymic acetylation of des-acetyl citrate lyase". Proc. Natl. Acad. Sci. U. S. A. 71: 1987–91. doi:10.1073/pnas.71.5.1987. PMID 4365579. 

[edit] External links

The CAS registry number for this enzyme class is 52660-22-7.

• IUBMB entry for 6.2.1.22

• KEGG entry for 6.2.1.22

• BRENDA entry for 6.2.1.22

• NiceZyme view of 6.2.1.22

• EC2PDB: PDB structures for 6.2.1.22

• PRIAM entry for 6.2.1.22

• PUMA2 entry for 6.2.1.22

• IntEnz: Integrated Enzyme entry for 6.2.1.22

• MetaCyc entry for 6.2.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008771: [citrate (pro-3S)-lyase ligase]

• AMIGO entry for GO code 0008771: [citrate (pro-3S)-lyase ligase]