(carboxyethyl)arginine beta-lactam-synthase

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In enzymology, a (carboxyethyl)arginine beta-lactam-synthase (EC 6.3.3.4) is an enzyme that catalyzes the chemical reaction

ATP + L-N₂-(2-carboxyethyl)arginine $\rightleftharpoons$ AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

[edit] References

IUBMB entry for 6.3.3.4
BRENDA references for 6.3.3.4 (Recommended.)
PubMed references for 6.3.3.4
PubMed Central references for 6.3.3.4
Google Scholar references for 6.3.3.4
Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI (2001). "Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities". J. Am. Chem. Soc. 123: 7388–98. doi:10.1021/ja004025+. PMID 11472170.
Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6: 583–9. doi:10.1016/S1367-5931(02)00392-7. PMID 12413541.
Bachmann BO, Li R, Townsend CA (1998). "beta-Lactam synthetase: a new biosynthetic enzyme". Proc. Natl. Acad. Sci. U. S. A. 95: 9082–6. doi:10.1073/pnas.95.16.9082. PMID 9689037.