(acyl-carrier-protein) phosphodiesterase

From Wikipedia, the free encyclopedia

In enzymology, a [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) is an enzyme that catalyzes the chemical reaction

holo-[acyl-carrier-protein] + H₂O $\rightleftharpoons$ 4'-phosphopantetheine + apo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[holo-[acyl-carrier-protein]]] and H₂O, whereas its two products are 4'-phosphopantetheine and [[apo-[acyl-carrier-protein]]].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.

[edit] References

IUBMB entry for 3.1.4.14
BRENDA references for 3.1.4.14 (Recommended.)
PubMed references for 3.1.4.14
PubMed Central references for 3.1.4.14
Google Scholar references for 3.1.4.14
Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver". J. Biol. Chem. 254: 8561–6. PMID 224058.
Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase". J. Biol. Chem. 242: 1776–81. PMID 4290442.
Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization". J. Biol. Chem. 280: 34675–83. doi:10.1074/jbc.M505736200. PMID 16107329.