(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring))

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In enzymology, a [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] (EC 2.7.11.4) is an enzyme that catalyzes the chemical reaction

ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate

Thus, the two substrates of this enzyme are ATP and [[[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]]], whereas its 3 products are ADP, [[[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]]], and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase. Other names in common use include kinase, BCK, BCKD kinase, BCODH kinase, branched-chain alpha-ketoacid dehydrogenase kinase, branched-chain 2-oxo acid dehydrogenase kinase, branched-chain keto acid dehydrogenase kinase, branched-chain oxo acid dehydrogenase kinase (phosphorylating), and STK2.

[edit] References

• IUBMB entry for 2.7.11.4
• BRENDA references for 2.7.11.4 (Recommended.)
• PubMed references for 2.7.11.4
• PubMed Central references for 2.7.11.4
• Google Scholar references for 2.7.11.4
• Paxton R, Harris RA (1982). "Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation". J. Biol. Chem. 257: 14433–9. PMID 7142221. 
• Wynn RM, Chuang JL, Cote CD, Chuang DT (2000). "Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase". J. Biol. Chem. 275: 30512–9. doi:10.1074/jbc.M005075200. PMID 10903321. 
• Chuang JL, Wynn RM, Chuang DT (2002). "The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase". J. Biol. Chem. 277: 36905–8. doi:10.1074/jbc.C200430200. PMID 12189132. 
• Popov KM, Hawes JW, Harris RA (1997). "Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases". Adv. Second. Messenger. Phosphoprotein. Res. 31: 105–11. PMID 9344245. 

[edit] External links

The CAS registry number for this enzyme class is 82391-38-6.

• IUBMB entry for 2.7.11.4

• KEGG entry for 2.7.11.4

• BRENDA entry for 2.7.11.4

• NiceZyme view of 2.7.11.4

• EC2PDB: PDB structures for 2.7.11.4

• PRIAM entry for 2.7.11.4

• PUMA2 entry for 2.7.11.4

• IntEnz: Integrated Enzyme entry for 2.7.11.4

• MetaCyc entry for 2.7.11.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047323: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide) kinase]

• AMIGO entry for GO code 0047323: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide) kinase]