ZFYV9E (protein)
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| Zinc finger FYVE domain-containing protein 9 (SARA) | |
|---|---|
| Symbol(s): | ZFYVE9 MADHIP |
| Other names: | Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Smad anchor for receptor activation, Receptor activation anchor, hSARA, Novel serine protease, NSP |
| Protein Structure/Function | |
| Protein type: | Anchoring protein |
| Domains: | 2 FYVE domains |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | ubiquitous |
| Subcellular localization: | Cytoplasm |
| Database Links | |
| Entrez: | 9372 |
| OMIM: | 603755 |
| UniProt: | O95405 |
Zinc finger FYVE domain-containing protein 9 or SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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