XCL2

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chemokine (C motif) ligand 2
Identifiers
Symbol	XCL2 SCYC2, SCM-1b
HUGO	10646
Entrez	6846
OMIM	604828
RefSeq	NM_003175
UniProt	Q9UBD3
Other data
Locus	Chr. 1 q24.2

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.^[1] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.^[2] Its gene is located on chromosome 1 in humans.^[3]

[edit] References

^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol 155 (1): 203-9. PMID 7602097.
^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem 273 (26): 16551-4. PMID 9632725.
^ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett 395 (1): 82-8. PMID 8849694.