William L. Nelson
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- For the World War II Medal of Honor recipient, see William L. Nelson (soldier).
Wiliam Lester Nelson (August 4, 1875–December 31, 1946) was an American farmer and politician from Columbia, Missouri. He represented Missouri as a Democrat in the United States House of Representatives for several terms: 1919-1921, 1925-1933 and 1935-1943.