White sponge nevus

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White sponge nevus, also known as a Cannon's disease, appears to follow a hereditary pattern as an autosomal dominant trait, with no sex preference. Although it is congeital in most cases, it can occur in childhood or adolescence.

It is caused by a mutation of the keratin 4 and keratin 13 genes.

It presents in the mouth, most frequently as a thick bilateral white plaque with a spongy texture, usually on the buccal mucosa, but sometimes on the labial mucosa, alveolar ridge or floor of the mouth. the gingival margin and dorsum of the tongue are almost never affected.

Although this condition is perfectly benign, it is often mistaken for leukoplakia. There is no treatment, but because there are no serious clinical complications, the prognosis is excellent.

[edit] References

• Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.