Viral evolution

From Wikipedia, the free encyclopedia

It has been suggested that Inter-host evolution be merged into this article or section. (Discuss)

It has been suggested that Intra-host evolution be merged into this article or section. (Discuss)

Viral evolution is a subfield of evolutionary biology that is specifically concerned with the evolution of viruses. Many viruses, in particular RNA viruses, have short generation times and realtively high mutation rates (on the order of one point mutation or more per genome per round of replication for RNA viruses). This elevated mutation rate, when combined with natural selection, allows viruses to quickly adapt to changes in their host environment.

Viral evolution is an important aspect of the epidemiology of viral diseases such as influenza, HIV, and hepatitis. It also causes problems in the development of successful vaccines and antiviral drugs, as resistant mutations often appear within weeks or months after the beginning of the treatment.

RNA viruses are also used as a model system to study evolution in the laboratory.

One of the main theoretical models to study viral evolution is the quasispecies model, as the viral quasispecies.

[edit] See also

[edit] Further reading

E. Domingo and C.K. Biebricher and M. Eigen and J.J. Holland (2002). Quasispecies and RNA Virus Evolution: Principles and Consequences. Landes Bioscience.
S.F. Elena and R. E. Lenski (2003). Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation. Nat. Rev. Genet. 4:457-469.