Unsolved problems in medicine

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Some unsolved problems in medicine include:

Ageing. Is it possible to stop it or slow it down?
Autism. What are the root causes of autism? Is autism a physiological or a mental disorder? Are all of the groupings of Autism Spectrum Disorders (ASD) really one disorder, or are they multiple disorders that display similar symptoms? Is Asperger's Syndrome really different from the other ASDs?
Cancer. Is it possible to develop a fundamental cure for all cancers?
HIV/AIDS. Can we develop a vaccine or cure that wipes out all strains of HIV? Where did HIV originate?
Hepatitis/Herpes. And other incurable pathogenic diseases and conditions. We can treat them but how can we eliminate them?
Hereditary diseases. Can gene therapy cure all diseases?
The Common Cold. Can we develop a vaccine or cure for all strains of the common cold?
Chronic Fatigue Syndrome. What is this disease, how is it caused and can it be cured?
The Whole-body transplant. Is it possible to perform a successful whole-body, or brain, transplant?
Will new technologies and smart software render dosimetry obsolete?
Simulation. How can we successfully model a normative body (and brain) such that an accurate, predictable simulation can be run in real-time, providing measurable results with a variety of experimental inputs?
Chronic Urticaria. What is the cause of such a disease? Can it be pinpointed as an autoimmunity or is it frankly idiopathic? Can it be cured or can the symptoms merely be controlled?
Spinal cord injury. Is it possible to completely repair lesions in the spinal cord, and other peripheral nerves, with 100% functional recovery?
Malaria How can both new and old tools be used to effectively control or eliminate this disease that kills one million people each year?