U.S. Route 378

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U.S. Highway 378 is a spur of U.S. Highway 78. It currently runs for 234 miles (377 km) from Conway, South Carolina at U.S. Route 501 to Washington, Georgia at U.S. Highway 78. It passes through the states of South Carolina and Georgia. It goes through the cities of Columbia, South Carolina and Sumter, South Carolina.

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