Two-pore channel

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two pore segment channel 1
Identifiers
Symbol TPCN1
HUGO 18182
Entrez 53373
OMIM 609666
RefSeq NM_017901
UniProt Q9ULQ1
Other data
Locus Chr. 12 q24.21
two pore segment channel 2
Identifiers
Symbol TPCN2
HUGO 20820
Entrez 219931
RefSeq NM_139075
UniProt Q8NHX9
Other data
Locus Chr. 11 q13.1

Two-pore channels: This small family of 2 members putatively forms cation-selective ion channels. They are predicted to contain two KV-style six-transmembrane domains, suggesting they form a dimer in the membrane. These channels are related to catsper channels channels and, more distantly, TRP channels.

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Membrane transport protein: ion channels

Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel

Ca: Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm

Na: Sodium channel: SCN4A - SCN5A - SCN9A - Epithelial sodium channel /Amiloride-sensitive sodium channel

K: Potassium channel: Voltage-gated (KvLQT1, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain/Resting ion channel

Cl: Chloride channel: Cystic fibrosis transmembrane conductance regulator

Transient receptor potential (TRPV6) - Cyclic nucleotide-gated ion channel - Two-pore channel

Porin: Aquaporin (1, 2, 3, 4)

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