From Wikipedia, the free encyclopedia
The tuberoinfundibular pathway refers to a population of dopamine neurons in the arcuate nucleus of the mediobasal hypothalamus (the 'tuberal region') that project to the median eminence (the 'infundibular region'). It is one of the four major dopamine pathways in the brain. Dopamine released at this site regulates the secretion of prolactin from the anterior pituitary gland.
Some antipsychotic drugs block dopamine in the tuberoinfundibular pathway, which can cause an increase in blood prolactin levels (hyperprolactinemia). This can cause abnormal lactation (even in men), disruptions to the menstrual cycle in women, visual problems, headache and sexual dysfunction.
Other major dopamine pathways include:
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Brain: telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) |
| primary sulci/fissures |
medial longitudinal, lateral, central, parietoöccipital, calcarine, cingulate |
| frontal lobe |
precentral gyrus (primary motor cortex, 4), precentral sulcus, superior frontal gyrus (6, 8), middle frontal gyrus (46), inferior frontal gyrus (Broca's area, 44-pars opercularis, 45-pars triangularis), prefrontal cortex (orbitofrontal cortex, 9, 10, 11, 12, 47) |
| parietal lobe |
postcentral sulcus, postcentral gyrus (1, 2, 3, 43), superior parietal lobule (5), inferior parietal lobule (39-angular gyrus, 40), precuneus (7), intraparietal sulcus |
| occipital lobe |
primary visual cortex (17), cuneus, lingual gyrus, 18, 19 (18 and 19 span whole lobe) |
| temporal lobe |
transverse temporal gyrus (41-42-primary auditory cortex), superior temporal gyrus (38, 22-Wernicke's area), middle temporal gyrus (21), inferior temporal gyrus (20), fusiform gyrus (36, 37) |
| limbic lobe/fornicate gyrus |
cingulate cortex/cingulate gyrus, anterior cingulate (24, 32, 33), posterior cingulate (23, 31),
isthmus (26, 29, 30), parahippocampal gyrus (piriform cortex, 25, 27, 35), entorhinal cortex (28, 34) |
| subcortical/insular cortex |
rhinencephalon, olfactory bulb, olfactory tract, corpus callosum (splenium, genu, rostrum), lateral ventricles, septum pellucidum, ependyma, internal capsule, corona radiata, external capsule, fornix (commissure of fornix), anterior commissure, posterior commissure |
| hippocampal formation |
dentate gyrus, hippocampus, subiculum |
| basal ganglia |
striatum (caudate nucleus, putamen), lentiform nucleus (putamen, globus pallidus), claustrum, extreme capsule, amygdala, nucleus accumbens |
| Some categorizations are approximations, and some Brodmann areas span gyri. |
