Trimethadione
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Trimethadione
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| Systematic (IUPAC) name | |
| 3,5,5-trimethyl-1,3-oxazolidine-2,4-dione | |
| Identifiers | |
| CAS number | |
| ATC code | N03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C6H9NO3 |
| Mol. mass | 143.141 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
X |
| Legal status |
℞ Prescription only |
| Routes | ? |
Trimethadione is an oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments; recent studies by Doctor Jianxin Bao, Ph.D., at Washington University in Saint Louis's Central Institute For The Deaf's Center For Presbyacusis and Aging suggest that trimethadione, along with other oxazolidinedione anticonvulsant medications may be useful in treating sensorineural hearing loss cases like those of Iraq war veterans- if the drug's side effects, like dizziness, can be lessened by modifying the drug so it does not cross into the brain itself.
If administered during pregnancy, fetal trimethadione syndrome may result. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]
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Barbiturates: Barbexaclone, Metharbital, Methylphenobarbital, Phenobarbital, Primidone
Hydantoins: Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin
Oxazolidinediones: Ethadione, Paramethadione, Trimethadione
Succinimides: Ethosuximide, Mesuximide, Phensuximide
Benzodiazepines: Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam
Carboxamides: Carbamazepine, Oxcarbazepine, Rufinamide Fatty acid derivatives: Valpromide, Valnoctamide
Carboxylic acids: Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine -- GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin
Others:- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine
Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam
Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide
