Travoprost

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Travoprost
Systematic (IUPAC) name
propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
Identifiers
CAS number	157283-68-6
ATC code	S01EE04
PubChem	656627
DrugBank	APRD01271
Chemical data
Formula	C26H35F3O6
Mol. mass	500.548 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C US
Legal status	Schedule VI US
Routes	Topical (eye drops)

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.^[1] It is also known by the brand name of Travatan, manufactured by Alcon Inc. Travoprost is a synthetic prostaglandin F 2α analogue. Its chemical name is isopropyl (Z)-7- [(1 R ,2 R ,3 R ,5 S )-3,5-dihydroxy-2-[(1 E ,3 R )-3-hydroxy-4-[(α,α,α-trifluoro- m -tolyl)oxy]-1- butenyl]cyclopentyl]-5-heptenoate.^[2]

Possible side effects of this medication are:

• May cause blurred vision;
• May cause eyelid redness;
• May permanently darken eyelashes;
• May cause eye discomfort;
• May eventually cause permanent darkening of the iris to brown (heterochromia);
• May cause a temporary burning sensation during use.
• May cause thickening of the eyelashes.

[edit] References

• http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500293.html
• Links to external chemical sources

[edit] Notes

v • d • e Antiglaucoma preparations and miotics (S01E)
Sympathomimetics	Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics	Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors	Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents	Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues	Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents	Dapiprazole, Guanethidine