Transporter associated with antigen processing

From Wikipedia, the free encyclopedia

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol TAP1 ABCB2
HUGO 43
Entrez 6890
OMIM 170260
RefSeq NM_000593
UniProt Q03518
Other data
Locus Chr. 6 p21.3
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol TAP2 ABCB3
HUGO 44
Entrez 6891
OMIM 170261
RefSeq NM_000544
UniProt Q03519
Other data
Locus Chr. 6 p21.3

Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family (ABC transporter).[1] It delivers cytosolic peptides into the endoplasmic reticulum (ER) where they bind to nascent MHC class I molecules. [2]

Tapasin may also have a role in stablising "empty" MHC class 1 molecules (i.e. those without peptides destined for presentation), epitope selection and quality control after peptide binding.

[edit] References

  1. ^ Daumke, O. (2001) Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains. Eur. J. Biochem., 268:4776-4786.
  2. ^ Suh, WK. (1994) Interaction of MHC class I molecules with the transporter associated with antigen processing. Science. Vol 264 5163:1322-1326.

[edit] External links

 This biochemistry article is a stub. You can help Wikipedia by expanding it.
 This cell biology article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org../../../t/r/a/Transporter_associated_with_antigen_processing.html"