Transient ischemic attack

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**Transient ischemic attack**
*Classification & external resources*
ICD-10	G45, I60-I69
ICD-9	435
DiseasesDB	13253
MedlinePlus	000730
eMedicine	emerg/604

A transient ischemic attack (TIA, often colloquially referred to as "mini stroke") is caused by the temporary disturbance of blood supply to a restricted area of the brain, resulting in brief neurologic dysfunction that usually persists for less than 24 hours.

1 Symptoms
2 Prognosis
3 Causes
4 Prevention
5 Treatment
6 References
7 External links

[edit] Symptoms

Symptoms vary widely from person to person depending on the area of the brain involved. The most frequent symptoms include temporary loss of vision (typically amaurosis fugax), difficulty speaking (dysarthria), weakness on one side of the body (hemiparesis), numbness usually on one side of the body, and loss of consciousness. If there are neurological symptoms persisting for more than 24 hours, it is classified as a cerebrovascular accident (stroke).

[edit] Prognosis

Patients diagnosed with a TIA are sometimes said to have had a warning for an approaching cerebrovascular accident. If the time period of blood supply impairment lasts more than a few minutes, the nerve cells of that area of the brain die and cause permanent neurologic deficit. One third of the people with TIA later have recurrent TIAs and one third have a stroke due to permanent nerve cell loss.

The ABCD² score can predict likelihood of subsequent stroke^[1]^[2].

The score is calculated as:

Age ≥ 60 years = 1 point
Blood pressure at presentation ≥ 140/90 mm Hg = 1 point
Clinical features

unilateral weakness = 2 points

speech disturbance without weakness = 1 point

Duration of attack

≥ 60 minutes = 2 points

10–59 minutes = 1 point

Diabetes = 1 point

Interpretation of score, the risk for stroke within 2 days:

Score 0-3 = 1% risk
Score 4-5 = 4% risk
Score 6–7 = 8% risk

[edit] Causes

The most common cause of a TIA is an embolus (a small blood clot) that occludes an artery in the brain. This most frequently arises from an atherosclerotic plaque in one of the carotid arteries (i.e. a number of major arteries in the head and neck) or from a thrombus (i.e. a blood clot) in the heart due to atrial fibrillation.

Other reasons include excessive narrowing of large vessels due to an atherosclerotic plaque and increased blood viscosity due to some blood diseases. TIA is related with other medical conditions like hypertension, heart disease (especially atrial fibrillation), migraine, cigarette smoking, hypercholesterolemia, and diabetes mellitus.

[edit] Prevention

[edit] Primary prevention

[edit] Secondary prevention

[edit] Tertiary prevention

[edit] Treatment

The mainstay of treatment following acute recovery from a TIA should be to diagnose and treat the underlying cause. It is not always immediately possible to tell the difference between a CVA (stroke) and a TIA. Most patients who are diagnosed at a hospital's Accident & Emergency Department as having suffered from a TIA will be discharged home and advised to contact their primary physician to organize further investigations.

An electrocardiogram (ECG) may show atrial fibrillation, a common cause of TIAs, or other arrhythmias that may cause embolisation to the brain. An echocardiogram is useful in detecting thrombus within the heart chambers. Such patients benefit from anticoagulation.

If the TIA affects an area supplied by the carotid artery, an ultrasound (TCD) scan may demonstrate carotid stenosis. For people with a greater than 70% stenosis within the carotid artery, removal of atherosclerotic plaque by surgery, specifically a carotid endarterectomy, may be recommended.

Some patients may also be given modified release dipyridamole or clopidogrel.

[edit] References

^ Johnston S, Rothwell P, Nguyen-Huynh M, Giles M, Elkins J, Bernstein A, Sidney S (2007). "Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack". Lancet 369 (9558): 283-92. DOI:10.1016/S0140-6736(07)60150-0. PMID 17258668.
^ Rothwell P, Giles M, Flossmann E, Lovelock C, Redgrave J, Warlow C, Mehta Z (2005). "A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack". Lancet 366 (9479): 29-36. PMID 15993230.