Transdermal patch

From Wikipedia, the free encyclopedia

A transdermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a time released dose of medication through the skin and into the bloodstream. Transdermal patches are used to deliver a wide variety of pharmaceuticals. The first commercially available prescription patch was approved by the U.S. Food and Drug Administration in December 1979, which administered scopolamine for motion sickness.^[1]^[2] The most well-known skin patch nowadays is the nicotine patch which releases nicotine to help quitting the habit of tobacco smoking. Other skin patches administer estrogen for menopause and to prevent osteoporosis after menopause, nitroglycerin for angina, and lidocaine to relieve the pain of shingles (herpes zoster). Recent developments expanded their use to the delivery of hormonal contraceptives, antidepressants and even pain killers. Some pharmaceuticals must be combined with substances, such as alcohol, that increase their ability to penetrate the skin in order to be used in a transdermal patch. Molecules of insulin and many other pharmaceuticals, however, are too large to pass through the skin.

In 2005, the Food and Drug Administration announced that they are investigating reports of death and other serious adverse events related to narcotic overdose in patients using Duragesic, the fentanyl transdermal patch for pain control. The Duragesic product label was subsequently updated to add safety information in June 2005.^[3]

1 Components
2 Types
3 Regulatory aspects
4 Notes
5 Further reading
6 See also

[edit] Components

The main components to a transdermal patch are:

Liner - Protects the patch during storage. The liner is removed prior to use.
Drug - Drug solution in direct contact with release liner
Adhesive - Serves to adhere the components of the patch together along with adhering the patch to the skin
Membrane - Controls the release of the drug from the reservoir and multi-layer patches
Backing - Protects the patch from the outer environment

[edit] Types

There are four main types of transdermal patches listed below.

[edit] Single-layer Drug-in-Adhesive

The adhesive layer of this system also contains the drug. In this type of patch the adhesive layer not only serves to adhere the various layers together, along with the entire system to the skin, but is also responsible for the releasing of the drug. The adhesive layer is surrounded by a temporary liner and a backing.

[edit] Multi-layer Drug-in-Adhesive

The multi-layer drug-in adhesive patch is similar to the single-layer system in that both adhesive layers are also responsible for the releasing of the drug. The multi-layer system is different however that it adds another layer of drug-in-adhesive, usually separated by a membrane (but not in all cases). This patch also has a temporary liner-layer and a permanent backing.

[edit] Reservoir

Unlike the Single-layer and Multi-layer Drug-in-adhesive systems the reservoir transdermal system has a separate drug layer. The drug layer is a liquid compartment containing a drug solution or suspension separated by the adhesive layer. This patch is also backed by the backing layer.

[edit] Matrix

The Matrix system has a drug layer of a semisolid matrix containing a drug solution or suspension. The adhesive layer in this patch surrounds the drug layer partially overlaying it.

[edit] Regulatory aspects

A transdermal patch is classified by the U.S. Food and Drug Administration as a combination product, consisting of a medical device combined with a drug or biological product that the device is designed to deliver. Prior to sale in the United States, any transdermal patch product must apply for and receive approval from the Food and Drug Administration, demonstrating safety and efficacy for its intended use.