Tolterodine

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Tolterodine
Systematic (IUPAC) name
2-[3-[bis(1-methylethyl)amino]- 1-phenyl-propyl]-4-methyl-phenol
Identifiers
CAS number	124937-51-5
ATC code	G04BD07
PubChem	60774
DrugBank	APRD00146
Chemical data
Formula	C22H31NO
Mol. mass	325.488 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	Approximately 96.3%.
Metabolism	?
Half life	1.9-3.7 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade name Detrol.

Tolterodine acts on M2 and M3 subtypes of muscarinic receptors whereas most antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. Tolterodine, although it acts on two types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (which is selective for M3 only) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects eg. hyposalivation, constipation, decreased gastric motility.

[edit] External links

• Detrol - FDA factsheet.
• Tolterodine
• Tolterodine (patient information)

v • d • e Urologicals (G04)
Acidifiers	Ammonium chloride, Calcium chloride
Urinary antispasmodics	Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium
For erectile dysfunction	Alprostadil, Apomorphine, Avanafil, Moxisylyte, Papaverine, Phentolamine, Sildenafil, Tadalafil, Udenafil, Vardenafil, Vendafidel, Yohimbine
Other urologicals	Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Phenazopyridine, Phenyl salicylate, Succinimide
For benign prostatic hypertrophy	5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens