TNA (nucleic acid)

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TNA is threose nucleic acid, a chemical similar to DNA or RNA but differing in the composition of its "backbone." TNA is not known to occur naturally in existing life on Earth.

DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by phosphodiester bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA.

DNA TNA hybrid chains have been made in the laboratory using DNA polymerase.

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[edit] References

Orgel, Leslie (Nov 2000). "A Simpler Nucleic Acid". Science 290 (5495): 1306 - 1307. DOI:10.1126/science.290.5495.1306.

Watt, Gregory (Feb 2005). "Modified nucleic acids on display". Nature Chemical Biology. DOI:10.1038/nchembio005.

Schoning, K; Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A (Nov 2000). "Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'->2') oligonucleotide system.". Science. PMID 11082060.

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Analogues of nucleic acids:	Types of Nucleic Acids	Analogues of nucleic acids:
Nucleobases:	Adenine \| Thymine \| Uracil \| Guanine \| Cytosine \| Purine \| Pyrimidine
Nucleosides:	Adenosine \| Uridine \| Guanosine \| Cytidine \| Deoxyadenosine \| Thymidine \| Deoxyguanosine \| Deoxycytidine
Nucleotides:	AMP \| UMP \| GMP \| CMP \| ADP \| UDP \| GDP \| CDP \| ATP \| UTP \| GTP \| CTP \| cAMP \| cADPR \| cGMP
Deoxynucleotides:	dAMP \| TMP \| dGMP \| dCMP \| dADP \| TDP \| dGDP \| dCDP \| dATP \| TTP \| dGTP \| dCTP
Ribonucleic acids:	RNA \| mRNA \| piRNA \| tRNA \| rRNA \| ncRNA \| sgRNA \| shRNA \| siRNA \| snRNA \| miRNA \| snoRNA \| LNA
Deoxyribonucleic acids:	DNA \| mtDNA \| cDNA \| plasmid \| Cosmid \| BAC \| YAC \| HAC
Analogues of nucleic acids:	GNA \| PNA \| TNA \| morpholino