Tissue factor pathway inhibitor

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tissue factor pathway inhibitor
Identifiers
Symbol	TFPI LACI
HUGO	11760
Entrez	7035
OMIM	152310
RefSeq	NM_001032281
UniProt	P10646
Other data
Locus	Chr. 2 q31-q32.1

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-TF complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5nM.

Contents 1 Genetics 2 Protein structure 3 See also 4 External link

[edit] Genetics

The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

[edit] Protein structure

TFPI has a relative molecular mass of 34000 to 40000 depending on the degree of proteolysis of the C-terminal region.

[edit] See also

• hemostasis

[edit] External link

• Mendelian Inheritance in Man (OMIM) 152310 (TFPI1), Mendelian Inheritance in Man (OMIM) 600033 (TFPI2)