Angiopoietin Receptors: Tie-1 & Tie-2

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tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol	TIE1 TIE, JTK14
HUGO	11809
Entrez	7075
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Other data
EC number	2.7.1.112
Locus	Chr. 1 p34-p33

TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
Identifiers
Symbol	TEK VMCM, TIE2, TIE-2, VMCM1, CD202b
HUGO	11724
Entrez	7010
OMIM	600221
RefSeq	NM_000459
UniProt	Q02763
Other data
Locus	Chr. 9 p21

Tie-1 and Tie-2 comprise the cell-surface receptors which bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

[edit] Angiopoietins

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation - but it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins