Talk:Thyronamine

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As one who works in a lab that studies T1AM & TAAR1, I have a few points for consideration:

• "3-iodothyronamine (T1AM) is the natural ligand" should be changed to "3-iodothyronamine (T1AM) is a natural, high-affinity ligand" because there are some known low-affinity ligands and potentially unknown ligands (as well as high-affinity ligands that are not endogenous).
• TAAR1 is a GPCR, but we have no real clue as to whether it is expressed on the cell surface or in intracellular membranes.
• "3-iodothyronamine causes a rapid drop in body temperature." ...when given in high doses as an injection. This effect isn't 100% consistent either. It certainly has major effects on metablism.

Scientizzle 01:21, 19 March 2006 (UTC)