Thomas Starzl

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Thomas Starzl (born March 11, 1926) is an American physician, researcher, and is an expert on organ transplants. He performed the first human liver transplants, and has often been referred to as "the father of modern transplantation."

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[edit] Life

Starzl was born on March 11, 1926 in Le Mars, Iowa, the son of newspaper editor and science fiction writer Roman Frederick Starzl. Originally intending to become a priest in his teenage years, Starzl's plans changed drastically when his mother died from breast cancer. He attended Westminster College in Fulton, Missouri, where he earned a Bachelor of Science degree in biology. Starzl attended Northwestern University Medical School in Chicago, where in 1950 he received a Master of Science degree in anatomy and in 1952 earned both a Ph.D. in neurophysiology and an M.D. with distinction.

Starzl was a researcher at the University of Colorado and later the University of Pittsburgh, in the then-unknown field of organ transplantation. He made an exceptional mark among the medical community creating surgical techniques that for a long time were only known to him. He reportedly worked up to three days straight on organ transplantation procedures as he was the only one who could perform them.

Starzl has authored or co-authored more than 2130 scientific articles, four books and 292 chapters. According to the Institute for Scientific Information, Starzl once averaged one paper every 7.3 days, making him one of the most prolific scientists in the world. In 1999, ISI identified Starzl as the most cited scientist in the field of clinical medicine, a measure of his work's lasting influence and utility.

Starzl's most notable accomplishments include:

  • Performing the first human liver transplant in 1963, and the first successful human liver transplant in 1967, both at the University of Colorado Health Sciences Center.[1]
  • Establishing the clinical utility of ciclosporin (cyclosporine) in 1982, and tacrolimus in 1991, both leading to FDA approval;
  • Development of multiple technical advances in organ preservation, procurement and transplant;
  • Delineating the indications and limitations of abdominal organ transplantation;
  • Defining the underlying basis for organ transplantation as a treatment of inherited metabolic diseases (thus providing the rationale for current-day gene therapy efforts);
  • Recognizing the causative role of immunosuppression in the development of post-transplant lymphoproliferative disease and other opportunistic infections and the utility of reversing the immunosuppressed state as the principle treatment;
  • Proposing microchimerism in organ transplant tolerance.

[edit] Awards and honors

Starzl has also received honorary degrees from 21 universities in the United States and abroad.

In 2006, at a celebration for his 80th birthday, the University of Pittsburgh renamed one its newest medical research buildings the Thomas E. Starzl Biomedical Science Tower in recognition of his achievements and contributions to the field. [2]

[edit] Retirement

Retired from clinical and surgical service since 1991, Dr. Starzl now devotes his time to research endeavors and remains active as professor of surgery at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center’s (UPMC) program named in his honor: the Thomas E. Starzl Transplantation Institute. Since his “retirement,” he has earned the additional distinctions of being one of the most prolific scientists in the world as well as the most cited scientist in the field of clinical medicine. (Source: University of Pittsburgh Medical Center)

[edit] See also

[edit] References

  1. ^ Milestones in Organ Transplantation National Kidney Foundation

[edit] External links

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