Thiamphenicol
From Wikipedia, the free encyclopedia
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Thiamphenicol
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| Systematic (IUPAC) name | |
| 2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide | |
| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C12H15Cl2NO5S |
| Mol. mass | 356.223 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | hepatic |
| Half life | 5.0 hours |
| Excretion | renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
none |
| Routes | IV, IM, O |
Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
[edit] Alternative names
- Dextrosulphenidol
- Thiophenicol
[edit] External links
- Overview at World Health Organization - Food and Agriculture Organization
- Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars) 64 (1): 33-8. PMID 15224555.
- Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy.". J Chemother 14 (6): 554-61. PMID 12583545.
