Talk:Theobald Smith
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Theobald Smith's Phenomenon or anaphylaxis was discovered by him through the use of guinea pigs which he injected with a small dose of blood serum containing diphtheria antitoxin. His experimenting with guinea pigs was conducted with the intention of determining a standardized or proper dose. He observed that a small dose of diphtheria antitoxin caused the guinea pigs to become highly susceptible to a somewhat larger dose of the same diphtheria antitoxin when injected several weeks later, perhaps causing the guinea pigs to die.
Other names for anaphylaxis include hypersusceptibility and protein sensitization.
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- 141.151.176.221 00:05, 7 August 2005 (UTC)
