Tenascin

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Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors.

There are four members of the tenascin gene family: tenascin-C, tenascin-R, tenascin-X and tenascin-W. Tenascin-C is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. Tenascin-R is found in the developing and adult nervous system. Tenascin-X is found primarily in loose connective tissue; mutations in the human tenascin-X gene can lead to a form of Ehlers-Danlos syndrome. Tenascin-W is found in the kidney and in developing bone.