Systemic inflammatory response syndrome

From Wikipedia, the free encyclopedia

You have new messages (last change).
It has been suggested that this article or section be merged with Sepsis. (Discuss)

In medicine, systemic inflammatory response syndrome (SIRS) is an inflammatory state of the whole body (the "system") without a proven source of infection. It is a serious medical condition.

Contents

[edit] Definition of SIRS

SIRS can be diagnosed when two or more of the following are present[1][2][3][4]:

  • Heart rate > 90 beats per minute
  • Body temperature < 36 or > 38°C
  • Tachypnea (high respiratory rate) > 20 breaths per minute or, on blood gas, a PaCO2 < 4.3 kPa (32 mm Hg)
  • White blood cell count < 4000 cells/mm3 or > 12000 cells/mm3 (< 4 x 109 or > 12 x 109 cells/L), or the presence of greater than 10% immature neutrophils.

[edit] Difference between SIRS and sepsis

SIRS with a confirmed infection,[4] proven through a positive blood culture or tissue sample positive for pathogenic organisms,[5] is called sepsis.

Simply stated:

SIRS + proof of infection = sepsis [1][2]

[edit] Complications of SIRS

SIRS can result in the multiple organ dysfunction syndrome.

[edit] Causes of SIRS

[edit] Relation to cytokine storm

SIRS can be considered to be a subset of cytokine storm, a general term (not commonly used in clinical medicine) for cytokine dysregulation.

[edit] See also

[edit] References

  1. ^ a b Irwin RS, Cerra FB, Rippe JM. Irwin and Rippe's Intensive Care Medicine. 5th Ed. Lippincott Williams & Wilkins. Hagerstown, MD. 2003. ISBN 0-7817-1425-7. Publisher's information on the book.
  2. ^ a b Marino PL. The ICU Book. 2nd Ed. Lippincott Williams & Wilkins. Hagerstown, MD. 1998. ISBN 0-683-05565-8. Publisher's information on the book.
  3. ^ Sharma S, Steven M. Septic Shock. eMedicine.com, URL: http://www.emedicine.com/MED/topic2101.htm Accessed on Nov 20, 2005.
  4. ^ a b Tslotou AG, Sakorafas GH, Anagnostopoulos G, Bramis J. Septic shock; current pathogenetic concepts from a clinical perspective. Med Sci Monit. 2005 Mar;11(3):RA76-85. PMID 15735579. Full Text.
  5. ^ Stedman's Medical Dictionary Lookup. URL: http://www.emedicine.com/asp/dictionary.asp?exact=Y&keyword=sepsis. Accessed on March 17, 2006.
  6. ^ Santhanam S, Tolan RW. Sepsis. eMedicine.com, URL: http://www.emedicine.com/ped/topic3033.htm Accessed on Mar 12, 2006.

[edit] Textbooks

[edit] External link

Retrieved from "http://en.wikipedia.org../../../s/y/s/Systemic_inflammatory_response_syndrome.html"
In other languages