Succinyl coenzyme A synthetase
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Succinyl coenzyme A synthetase catalyzes the formation of succinate and coenzyme-A, a 4-carbon metabolite, from succinyl-CoA. Succinyl-CoA synthetase catalyzes a reversible step in the citric acid cycle, which involves the substrate-level phosphorylation of GDP.
Johnson et al. (1998) describe two isoforms of Succinyl-CoA synthetase in mammals, one which specifically uses ATP for synthesis, and one which utilizes GTP. The crystal structure of Succinyl-CoA synthetase alpha subunit (ATP-binding isoform) was determined by Joyce et al. (2000) to a resolution of 2.10 A, with PDB code 1CQJ. [1]
This enzyme is also known as succinate thiokinase in some texts.
[edit] Sources
- Johnson, J. D., Mehus, J. G., Tews, K., Milabetz, B. I., and Lambeth, D. O. (1998) J. Biol.Chem. 273, 27580-27586
- Joyce, M. A., Fraser, M. E., James, M. N. G., Bridger, W. A., and Wolodko, W. T. (2000) Biochemistry 39, 17-25
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Citrate synthase - Aconitase - Isocitrate dehydrogenase - Oxoglutarate dehydrogenase - Succinyl coenzyme A synthetase - Succinate - coenzyme Q reductase (SDHA, SDHB, SDHC, SDHD) - Fumarase - Malate dehydrogenase
