Steroid 11-beta-hydroxylase
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cytochrome P450, family 11, subfamily B, polypeptide 1
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| Identifiers | |
| Symbol | CYP11B1 CYP11B |
| HUGO | 2591 |
| Entrez | 1584 |
| OMIM | 610613 |
| RefSeq | NM_001026213 |
| UniProt | P15538 |
| Other data | |
| EC number | 1.14.15.4 |
Steroid 11-beta-hydroxylase is a steroid hydroxylase found in the zona fasciculata.
Contents |
[edit] Function
It generates cortisol from 11-deoxycortisol and corticosterone from 11-deoxycorticosterone. Note the extra "-OH" added at the 11 position (near the center, on ring "C"):
[edit] Location in pathway
[edit] Clinical significance
A mutation is associated with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.
[edit] Additional images
 Corticosteroid biosynthetic pathway in rat |
 Steroid numbering |
[edit] External links
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Side-chain cleavage - 21-hydroxylase - 18-hydroxylase - 11-beta-hydroxylase
