STAT5

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signal transducer and activator of transcription 5A
Identifiers
Symbol STAT5A STAT5
HUGO 11366
Entrez 6776
OMIM 601511
RefSeq NM_003152
UniProt P42229
Other data
Locus Chr. 17 q11.2
signal transducer and activator of transcription 5B
Identifiers
Symbol STAT5B
HUGO 11367
Entrez 6777
OMIM 604260
RefSeq NM_012448
UniProt P51692
Other data
Locus Chr. 17 q11.2

STAT5 refers to two highly related proteins, STAT5a and STAT5b. STAT5a and STA5b are encoded by separate genes, but are 90% identical at the amino acid level. [1]

[edit] References

  1. ^ Grimley PM, Dong F, Rui H. (1999) "Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation." in Cytokine Growth Factor Rev Volume 10 (2), pages 131-57. Entrez PubMed 10743504
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Transcription factors and intracellular receptors

CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)

Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)

Basic leucine zipper: C/EBP - CREB - AP-1

Basic helix-loop-helix leucine zipper: MITF - SREBP

Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)

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Signal transduction, carrier proteins: adaptor proteins

14-3-3 - Caveolin - Cortactin - Death Inducing Signaling Complex - Interferon regulatory factors - Paxillin - PIAS - SMAD - SOCS - STAT (STAT1, STAT3, STAT5)

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