Spectinomycin

From Wikipedia, the free encyclopedia

Spectinomycin
Systematic (IUPAC) name
(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- 4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino) decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Identifiers
CAS number	1695-77-8
ATC code	J01XX04
PubChem	15541
DrugBank	APRD01232
Chemical data
Formula	C14H24N2O7
Mol. mass	332.35 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin®) is an aminocyclitol antibiotic produced by the bacterium Streptomyces spectabilis. It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis. It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. Side effects include itching, chills, and red rash.

Antibiotics (J01) edit

v • d • e Tetracyclines (J01AA) Chlortetracycline, Demeclocycline, Doxycycline, Lymecycline, Minocycline, Oxytetracycline, Tetracycline v • d • e Penicillins (J01C) Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, Nafcillin, Piperacillin, Pivampicillin, Ticarcillin v • d • e Cephalosporin Antibiotics (J01D) First Generation Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole Second Generation Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam Third Generation Cefcapene, Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef Fourth Generation Cefclidine, Cefepime, Cefetecol,Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome v • d • e Sulfonamides (J01E) Mafenide, Prontosil, Sulfacetamide, Sulfamethizole, Sulfamethoxazole (with Trimethoprim in Co-trimoxazole), Sulfanilimide, Sulfasalazine, Sulfisoxazole v • d • e Glycopeptides (J01, and others) Macrolides: Azithromycin, Clarithromycin, Dirithromycin, Erythromycin, Roxithromycin Others: Monobactams (Aztreonam), Teicoplanin, Vancomycin v • d • e Aminoglycosides (J01G) Amikacin, Gentamicin, Kanamycin, Neomycin, Netilmicin, Streptomycin, Tobramycin, Paromomycin, Hygromycin, spectinomycin v • d • e Quinolones (J01M) Fluoroquinolones Ciprofloxacin, Enoxacin, Fleroxacin, Gatifloxacin, Gemifloxacin, Grepafloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Norfloxacin, Ofloxacin, Pefloxacin, Prulifloxacin, Rufloxacin, Sparfloxacin, Temafloxacin, Trovafloxacin, Sitafloxacin Other quinolones Cinoxacin, Flumequine, Nalidixic acid, Oxolinic acid, Pipemidic acid, Piromidic acid, Rosoxacin v • d • e Polypeptides Antibiotics (J01XB, and others) Bacitracin, Colistin, Hitachimycin, Polymyxin B v • d • e 'Other Antibiotics ' Chloramphenicol, Clindamycin, Dalfopristin, Ethambutol, Fosfomycin, Furazolidone, Isoniazid, Linezolid, Metronidazole, Nitrofurantoin, Pyrazinamide, Quinupristin, Rifampin