Sparfloxacin
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Sparfloxacin
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| Systematic (IUPAC) name | |
| 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin- 1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid |
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| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H22F2N4O3 |
| Mol. mass | 392.41 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 92% |
| Protein binding | 45% |
| Metabolism | Hepatic glucuronidation Cytochrome P450 system not involved |
| Half life | 16 to 30 hours |
| Excretion | Fecal (50%) and renal (50%) |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Oral |
Sparfloxacin (spar FLOX a sin), trade names Zagam® and Zagam Respipac, is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Zagam is no longer available in the United States.
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| Fluoroquinolones | Ciprofloxacin, Enoxacin, Fleroxacin, Gatifloxacin, Gemifloxacin, Grepafloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Norfloxacin, Ofloxacin, Pefloxacin, Prulifloxacin, Rufloxacin, Sparfloxacin, Temafloxacin, Trovafloxacin, Sitafloxacin |
| Other quinolones | Cinoxacin, Flumequine, Nalidixic acid, Oxolinic acid, Pipemidic acid, Piromidic acid, Rosoxacin |
